Ebola virus disease is a severe and often fatal illness caused by the Ebola virus. It is transmitted to humans through contact with infected animals, such as fruit bats or monkeys, and then spreads through human-to-human transmission via bodily fluids. Symptoms of Ebola virus disease include fever, severe headache, muscle pain, fatigue, diarrhea, vomiting, and in some cases, internal and external bleeding. The disease has a high mortality rate, with outbreaks often occurring in remote areas of Central and West Africa. Research on Ebola virus disease focuses on understanding the virus's biology, transmission, and pathogenesis, as well as developing vaccines and treatments to prevent and control outbreaks. Recent advances in research have led to the development of promising experimental treatments and vaccines, such as the rVSV-ZEBOV vaccine, which have shown efficacy in clinical trials. Ongoing research efforts are aimed at improving diagnosis, treatment, and prevention strategies to better manage and control future outbreaks of Ebola virus disease.